Explanation:
Antipsychotics, methylphenidate, acetazolamide, aspirin, cimetidine, thiazides, fluoxetine and sodium bicarbonate increase tricyclic antidepressant (TCA) concentrations. Cigarette smoking decreases their concentration through its action on the 1A2 enzyme.
Explanation:
Antipsychotics, methylphenidate, acetazolamide, aspirin, cimetidine, thiazides, fluoxetine and sodium bicarbonate increase tricyclic antidepressant (TCA) concentrations. Cigarette smoking decreases their concentration through its action on the 1A2 enzyme.